A " Generalized seizure " corresponds to

an ictal manifestation whose initial

semeiology indicates, or is consistent

with, more than minimal involvement of

both cerebral hemispheres. A network is a

functionally and anatomically connected set of cortical

and subcortical brain regions in which activity in any

one part affects activity in all others. A system is a

group of independent but interrelated elements

(networks) comprising a unified whole. A considerable

amount of evidence supports the existence of specific

cortical and subcortical networks in the genesis,

expression and control of generalized seizures. Animal

and human data suggested that the so-called

generalized seizures involve selective networks while

sparing others. A greater understanding of those

systems and networks, thoroughly debated in this

book, will ultimately lead to improved targeted

therapies for so-called generalized epilepsies.